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Python jobs in San Francisco

San Francisco still pays the highest absolute base salaries for Python engineers. Hybrid is the norm — 2–3 days in office for most listings. We surface the roles from SF-headquartered companies' ATS directly.

10 matching roles in cache · refreshed daily

About these roles

SF Python hiring concentrates at a few clear lanes: ML-platform work at AI-native companies (OpenAI, Anthropic, Adept, Mistral US, Hugging Face SF), backend engineering at well-funded YC-graduate scale-ups, data-platform roles at fintech (Stripe, Block, Plaid, Brex, Mercury), and infrastructure tooling at companies building developer products in Python (dbt Labs, Modal, Replicate). Comp ranges $170-260k base at senior IC, +30-40% in equity for the AI tier. Hybrid expectation is 2-3 days for most; a small remote-friendly tail exists but is shrinking through 2025-2026 as the AI cluster pulls people back. Take-home assessments and system design rounds dominate the interview shape — algorithm screens are increasingly rare past the recruiter call.

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